What is incidental pulmonary embolism, and why does it matter?

Incidental pulmonary embolism is PE discovered on a contrast-enhanced CT ordered for a different clinical reason, such as oncology staging, trauma, or post-surgical follow-up. The patient was not referred for a PE workup, and PE is not what the radiologist is looking for. It affects approximately 3.6% of oncologic CT scans. Untreated, it carries a risk of recurrence, hemodynamic deterioration, and emergency readmission. Identified at the time of the scan, it can be managed before the patient is discharged.

What is the risk of patient leakage with missed incidental PE?

When incidental PE is not detected at the time of the scan, the patient is discharged without management. In the IGR study (Ammari et al., 2024), 13.5% of patients with a missed or delayed incidental PE diagnosis were discharged and later readmitted, sometimes as an emergency. The patient re-enters care at a later stage, in a worse clinical state, and often at higher cost. Detection at the time of the original scan closes that gap before the patient leaves the facility.

How is CINA-iPE different from CINA-PE?

CINA-PE is designed for dedicated CT pulmonary angiography (CTPA) in symptomatic patients with suspected PE. The scan uses pulmonary timing, which produces high contrast opacification of the pulmonary arteries (above 200 HU), and the algorithm is optimized for that protocol. CINA-iPE is designed for Thoracic-Abdominal-Pelvic (TAP) scans and other contrast-enhanced CT acquired for different clinical indications, typically with portal timing. In these scans, contrast in the pulmonary arteries is much lower, generally below 200 HU, and clots are harder to identify. The two products use separate algorithms built for different imaging conditions. They can run on the same infrastructure without interference.

CINA-Cspine

AI Triage for Acute
Cervical Spine Fractures
on Non-Contrast CT

A trauma patient comes in. A CT is acquired. What happens next determines whether a fracture is caught in the acute window or missed until it causes harm. CINA-CSpine analyzes every qualifying CT automatically, flags suspected fractures before the radiologist opens the case, and delivers preview with the suspected fracture identified.

CE-marked

MDR Class IIb

FDA-cleared

Class II

The Fracture That Cannot Wait, and the One That Cannot Be Seen.

Cervical spine fractures in trauma present in different ways. Some are obvious. Some are not. Both carry consequences when detection is delayed. Earlier surgical decompression is associated with better neurological recovery; delayed decompression is linked to significantly worse outcomes.

Displaced Fractures

A displaced cervical fracture fragment is surgically urgent. Spinal cord compression, instability, and neurological deterioration are immediate risks. The clinical question is already open the moment the scan is acquired. A case that waits behind routine studies while the neurosurgical team waits for a result is a case that is losing time.

Non-Displaced Fractures

Non-displaced fracture lines are radiologically subtle. They require careful attention and often specific windowing to identify. In a high-volume trauma setting, a non-displaced fracture on a cervical CT that is read quickly under pressure can be missed, particularly by trainees reading after office hours.

Cervical Spine Fracture Detection

output-into-computer-cspine-ous-sagittal

Triage and notification tool for non-contrast-enhanced cervical spine CT in adults with suspected acute cervical fracture. Designed to flag acute cervical spine fracture including non-displaced fracture lines and displaced fracture fragments.

Sensitivity

0 %

Specificity

0 %

AUC

Detection Coverage

C1 through C7 Non-displaced fracture lines Displaced fracture fragments

Sensitivity

0 %

Specificity

0 %

AUC

Detection Coverage

C1 through C7 Non-displaced fracture lines Displaced fracture fragments

Clinical Evidence

Peer-reviewed studies validating CINA-CSpine performance.

2025

Cotena et al.

ECR 2025

In a large-scale real-world validation, 1,055 anonymized non-contrast CT scans were analyzed from a US teleradiology network, representing typical trauma practice with a 7.2% case prevalence, comparable to real clinical settings. The study covered eight CT manufacturers and 48 scanner models. Ground truth was established by a board-certified musculoskeletal radiologist.

sensitivity across 8 manufacturers, 48 scanner models

0 %

2026

Sung et al.

Diagnostics

In a peer-reviewed multicenter, multinational, multivendor study across a US teleradiology network, a French teleradiology company, and UC Irvine Medical Center, CINA-CSpine was evaluated on 328 non-contrast cervical CT cases. Four radiologists independently established ground truth for case-level diagnosis, fracture localization, and vertebral level labeling across 5 scanner manufacturers.

agreement in vertebral level labeling (C1 through C7)

0 %

Frequently Asked Questions

What does CINA-CSpine detect, and what scan type does it require?

CINA-CSpine is a triage and notification tool for non-contrast-enhanced CT of the cervical spine in adults with suspected acute cervical fracture. It flags suspected non-displaced fracture lines and displaced fracture fragments. It requires a non-contrast CT with a bone or sharp reconstruction kernel and at least five consecutive visible cervical vertebrae in the field of view. It is not designed to detect vertebral compression fractures.

How does CINA-CSpine fit into the emergency radiology workflow?

CINA-CSpine integrates via standard DICOM into the existing PACS and worklist. Every qualifying cervical CT is analyzed automatically, with no manual trigger required. Suspected fracture cases are flagged in the worklist before interpretation begins. The radiologist reviews the full case and makes the final diagnostic decision.

CINA-CSpine, medical images analysis software, a medical device manufactured by Avicenna.AI. This medical device is reserved for health professionals. The performance and outputs of this tool may differ slightly according to the software version and applicable regulations.

This software has been designed and manufactured according to the EN ISO 13485 Quality management system. Read the instructions in the notice carefully before any use.

– Instructions for Use are available.

– Manufacturer: Avicenna.AI (France).

– Medical device Class IIb following the European Regulation on Medical Device (EU) 2017/745.

– Medical device Class II following the Code of Federal Regulations of the United States of America 21CFR on Medical Devices.

Download OUR CASE STUDY

Complete the form below to access the CINA Trauma case study.

Intracranial Hemorrhage detection

AI-powered detection of intracranial hemorrhage on non-contrast CT, covering all hemorrhage types across stroke and trauma pathways.

CINA-VCF

Vertebral Compression Fracture

AI-powered detection of vertebral compression fractures on contrast or non-contrast CT scans of the chest and abdomen, covering T1 through L5

CINA-Cspine

AI Triage for Acute Cervical Spine Fractures on Non-Contrast CT

CE-marked

FDA-cleared

The Fracture That Cannot Wait, and the One That Cannot Be Seen.

Displaced Fractures

Non-Displaced Fractures

Cervical Spine Fracture Detection

Detection Coverage

Detection Coverage

Clinical Evidence

Cotena et al.

Sung et al.

Frequently Asked Questions

Download OUR CASE STUDY

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AI Triage for Acute
Cervical Spine Fractures
on Non-Contrast CT